The Effect of Candesartan on Renal Function and Renin-Angiotensin-Aldosterone System (RAAS) in Hypertensive Patients

Abstract

Abstract

Nearly half of all strokes, heart failure, myocardial infarction, and kidney damage are caused by hypertension, one of the most important drugs used extensively to treat hypertension is candesartan. In the present study, on a sample of patients with hypertension, the impact of candesartan was examined. The impact of the medication was determined on a number of critical hormones, including angiotensin, renin, and aldosterone as well as the concentration of creatinine, uric acid, and blood urea. The one hundred and twenty individuals who participated in the study were divided into three groups. Each group had forty individuals, group one (G1) (negative control) included apparently healthy individuals with normal blood pressure, while group two (G2) included individuals with high blood pressure who were being treated with a drug other than candesartan; this group represents positive control. As for group three (G3), it included individuals with high blood pressure who were being treated with a drug candesartan. The findings demonstrated that patients with hypertension who were treated with candesartan had lower levels of blood urea, uric acid, and creatinine. With regard to the hormones angiotensin, renin and aldosterone, the results indicated that the levels of these hormones in patients taking candesartan were close to normal levels in healthy people.